AFI may refer to:

• Address-family identifier, a 16 bit field of the Routing Information Protocol
• AFI (band), an American rock band
  • AFI (2004 album), a retrospective album by AFI released in 2004
  • AFI (2017 album), the tenth studio album by AFI
• Afi, Iran, a village in East Azerbaijan Province, Iran
• Agencia Federal de Investigación (Federal Investigations Agency), a Mexican agency
• Air Force Instruction, documented instructions for members of the United States Air Force
• Akrukay language
• Alliance for Financial Inclusion, an organization of central bank regulators from the developing world
• American Film Institute, an independent non-profit film organization
• American Football Israel, a nonprofit sports organization
• Amniotic fluid index, a measure of the amount of amniotic fluid of a fetus
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