Mark Murphy may refer to:

Sports

• Mark Murphy (ice hockey) (born 1976), American ice hockey player who plays for the DEG Metro Stars
• Mark Murphy (safety, born 1955) (born 1955), retired American football player, now President and CEO of the Green Bay Packers
• Mark Murphy (safety, born 1958) (born 1958), retired American football player
• Mark Murphy (soccer) (born 1984), American soccer player

Other

• Mark Murphy (singer) (1932–2015), American jazz singer
• Mark Murphy (author), author and expert on organizational leadership and employee engagement

See also

• Marc Murphy (born 1987), Australian rules footballer
• Marc Murphy (chef) (born c. 1969), Italian chef